Assuntos
Cardiomiopatias/diagnóstico , Cardiomiopatias/fisiopatologia , Teste de Esforço/tendências , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Adulto , Idoso , Teste de Esforço/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Prognóstico , Estudos ProspectivosRESUMO
CONTEXT: Neopterin serum concentration increases in the presence of renal dysfunction. OBJECTIVE: We sought to determine the relationship between admission serum neopterin levels and worsening renal function (WRF) in patients with heart failure (HF). METHODS: We prospectively measured serum neopterin levels in patients with HF and the patients were subdivided into two groups: with and without WRF during hospital admission. RESULTS: Logistic regression analysis showed that high serum neopterin levels at admission were associated with a greater likelihood of developing WRF. CONCLUSIONS: Patients admitted to hospital with HF, elevated serum neopterin levels are associated with an increased risk of developing WRF.
Assuntos
Insuficiência Cardíaca/sangue , Neopterina/sangue , Insuficiência Renal/sangue , Idoso , Feminino , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/diagnóstico , Humanos , Rim/metabolismo , Rim/patologia , Testes de Função Renal , Masculino , Pessoa de Meia-Idade , Miocárdio/metabolismo , Miocárdio/patologia , Prognóstico , Estudos Prospectivos , Análise de Regressão , Insuficiência Renal/diagnóstico , Insuficiência Renal/etiologia , Fatores de Risco , Sensibilidade e Especificidade , Índice de Gravidade de DoençaRESUMO
At present, the study into inflammatory markers has become a new tool which is most useful for establishing the prognosis of patients with acute coronary syndrome. The inflammatory substrate involved is acute coronary syndrome is extremely complex, with a large number of factors involved both in its activation and its modulation. It is known that C-reactive protein play a key role in the physiopathology of the atherosclerosis. Furthermore, scientific literature reports that the existence of a circadian rhythm in the triggering of cardiovascular accidents can suggest the implication of, or association with these physiological rhythms that show activity peaks at particular times of the day or night. Keeping in mind the potential association between inflammation and circadian rhythm, a better understanding of the kinetics of said markers could lead to improvements in their use in cardiovascular diseases. Considering the diversity of the diurnal variations in the intrinsic properties of the cardiovascular system, these should be kept in mind during the design of in vivo experimental studies. As such, the information available reinforces our opinion when suitably validating the biomarkers and the need to demonstrate their reliability, stability, and lack of variability and standardise the methodology of their measurement.
